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Published in French in Tropical Dental Journal Volume 45 - March 2022 pages 65-68
Good long-term tolerance of thalidomide during the treatment of severe oral aphtosis
Authors : F.A. Wanvoegbe, A. Turcu, S. Bancole, A. Jacquin-Piques, B. Bach, H. Devilliers, A. Agbodande, A. Azon-Kouanou, G. Muller, J.F. Besancenot, P. Bielefeld - Benin
La thalidomide est un traitement de référence des aphtoses récurrentes et résistantes aux traitements conventionnels. Il peut être responsable de plusieurs effets secondaires dont une polyneuropathie sensitivo-motrice. Cette neuropathie périphérique est un effet indésirable très fréquent, potentiellement grave, pouvant entraîner des lésions irréversibles. Nous rapportons ici un cas d’aphtose buccale récurrente traitée par thalidomide à faible dose avec une bonne évolution et une bonne tolérance au long cours.
Thalidomide is a standard treatment for recurrent aphtosis resistant to conventional treatments. It can be responsible for several side effects including sensory-motor polyneuropathy. This peripheral neuropathy is a very common and potentially serious side effect that can lead to irreversible damage. We report here a case of recurrent oral aphtosis treated with low-dose thalidomide with good evolution and good long-term tolerance.
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