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Tropical Dental Journal - 1st Pan African international dental journal


Tropical Dental Journal



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Published in French in Tropical Dental Journal Volume 45 - June 2022 pages 5-12

Docteur Saint Honoré Ohoueu Seka In vitro antifungal activities of Allium sativum and Annona muricata extracts on the growth of Candida albicans hospital strain of oral originIn vitro antifungal activities of Allium sativum and Annona muricata extracts on the growth of Candida albicans hospital strain of oral origin est évalué 1 étoiles par les abonnés Tropical Dental Journal Online

Authors : S.H. Ohoueu Seka, J.A. Adouko Aka, B.N. Djyh, E.K. Bolou Gbouhoury, M. Ayé, A. Bidié - Ivory Coast


Résumé

Introduction : La candidose buccale est une infection fongique peu fréquente chez le sujet sain et quasi présente chez le sujet infecté par le virus du VIH-SIDA. Le caractère récidivant des candidoses buccales chez les sujets infectés du VIH-SIDA, dû à la résistance du Candida albicans aux antifongiques conventionnels dont le traitement long et onéreux, et le niveau socio-économique faible des patients ont motivé la présente étude. Elle a pour objectif de montrer l’activité inhibitrice ou antifongique des extraits d’Allium sativum et Annona muricata sur Candida albicans.
Matériel et méthode : Des extraits éthanolique et aqueux d’Allium sativum et Annona muricata obtenus après l’étude tri-photochimique, ont été testés par la méthode de double dilution en tube penchée sur deux souches de Candida albicans de profils différents.
Résultats : Les résultats ont montré que l’extrait hydroalcoolique d’Allium sativum a un effet fongicide remarquable sur les survivances du Candida albicans résistant à l’Amphotéricine B avec la valeur de Concentration Minimale Fongicide (CMF) égale à 100 mg/mL et sur Candida albicans sensible à tous les antifongiques conventionnels avec la valeur de CMF égale à 50 mg/mL.
Conclusion : L’extrait hydro-éthanolique d’Allium sativum pourrait contribuer efficacement au traitement des candidoses buccales.

Abstract
In vitro antifungal activities of Allium sativum and Annona muricata extracts on the growth of Candida albicans hospital strain of oral origin

Introduction: Oral candidiasis is a fungal infection that is uncommon in healthy individual and almost always present in HIV-AIDS infected individual. Recurrent nature of oral candidiasis in HIV-AIDS infected subjects, due to resistance of Candida albicans to conventional antifungal agents, including long and expensive treatment, and low socio-economic level of patients, motivated this present study. The aim of the study was to show inhibitory or antifungal activity of Allium sativum and Annona muricata extracts on Candida albicans.
Material and method: Ethanolic and aqueous extracts of Allium sativum and Annona muricata were prepared and tested on two strains of Candida albicans with different profiles.
Results: Results showed that hydroalcoholic extract of Allium sativum has a remarkable fungicidal effect on Amphotericin B resistant Candida albicans survivors with the value of Minimum Fungicidal Concentration (MFC) equal to 100mg/mL and on Candida albicans sensitive to all conventional antifungals with the value of MFC equal to 50 mg/mL.
Conclusion: Hydroethanol extract of Allium sativum could contribute effectively to the treatment of oral candidiasis.

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